A meeting of like minds at the Combined Logistics Networks annual meeting in Bangkok from May 25-30, 2010, aims to be a good start to rebounding quickly from the impacts of the Global Financial Crisis.
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As if he hasn't been through enough after being chewed up and spit out by the Kardashian Khaos Kreator, poor (figuratively, not literally) Kris Humphries was booed during a preseason Nets' game at Madison Square Garden. ESPN says he was "booed lustily" when he came into the game during the second quarter, and then again every time he touched the ball for the six minutes he stayed in the game. Ouch!
But then, after he came out of the game, the crowd chanted "We want Humphries! We want Humphries!" off and on for the rest of the game. Wow, the crowd's reaction perfectly captures the world's feelings towards all things Kardashian: you really hate them but the minute they go away you realize you can't live without them. Boo! Wait, where are you going? Come baaaaack! [ESPN]
Last night, during his Home for the Holidays concert in Toronto, Justin Bieber brought his three-year-old sister, Jazmyn, on stage with him. He and Jazzy sang part of his hit "Baby" before having an extended conversation about how she cut her own hair and shaved her 2-year-old brother's head while she was at it. She also announced that she is a princess. Of course, the audience oohed and ahhed as their hearts melted from the sweetness. He seems refreshingly unguarded and genuine when talking to her?quite a welcome contrast to the manufactured side of him we so often see. Oh, and Jazzy tripped as she walked off the stage, which tipped the scales from "very cute" to "off-the-charts adorable." [HuffPo]
I always like to put a little bit of makeup on. I'm not the kind of person that just slops around in sweatpants. I like to feel a little more together - you never know who you're going to see out there!
Actually, I do know who I'm going to see out there: no paparazzi and no one I really care about, so I don't mind sweating it up on occasion. But I can see, were you forced to be camera-ready at all hours of the day or night, why you might ditch the comfy pants in favor of something more flattering. [People]
Jetlag+Vodka=blackout.
Us?blackout=irrational confusion.
jail+guilt+press=lesson learned.
Sauli+Adam+hangover burgers= laughing bout it. :)
That is one complicated equation! [Twitter]
I've lost my appetite. Plus the people that are running for mayor?I know this is terrible?I look at them and I don't see myself in that crowd. They're like a guy on a date that you can tell he just can't wait to get his hand up your blouse before even the lights go out in the theater. They're all just so horny for it. Horny for their own ascension. Whereas for me, I've got a job now?I've got a good job.
He might not be horny enough, and he might be too rash to have been a good mayor anyway. But it's a damn shame we won't get to see what his campaign ads would have looked like! [E! Online]
I don't think there's necessarily any timetable for it. We're definitely excited about being parents at some point, but I think whenever that happens, we'll embrace it and be excited for it. There's no real sense of urgency at this point.
Phew. Now we can give our undivided attention to Kate Middleton's midsection. [People]
[S]peculation is swirling over what [Prince] William is going to get Kate for Christmas, [and] the general consensus at this point is that the Duchess of Cambridge is getting a puppy.
Hmm, that could mean that she is not pregnant, because who buys a puppy right when they're having a baby?too many poops to clean up after at once! Or it could mean that she is pregnant because they can just pay someone else to clean up after the puppy and then they can have it snuggle with the baby to keep it warm at night in that drafty old castle they'll be living in. [Us Weekly]
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Source: androidcommunity.com --- Thursday, December 22, 2011
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ScienceDaily (Dec. 22, 2011) ? Life is complicated enough, so you can forgive the pioneers of DNA biology for glossing over transcriptional elongation control by RNA polymerase II, the quick and seemingly bulletproof penultimate step in the process that copies the information encoded in our DNA into protein-making instructions carried by messenger RNA.
In a new report appearing in the Dec. 23, 2011, issue of Molecular Cell, researchers at the Stowers Institute for Medical Research add not just a new layer, but a whole new dimension to transcriptional elongation control with evidence that for each class of genes transcribed by RNA polymerase II (Pol II), there exists a specific class of elongation factors.
The Stowers team, led by investigator Ali Shilatifard, Ph.D., discovered that ELL, short for eleven-nineteen lysine-rich leukemia, not only belongs to an assemblage of transcription elongation factors, which Shilatifard's lab had identified as the "Super Elongation Complex" (SEC) a few years ago, but also that ELL is part of a distinct "Little Elongation Complex" (LEC), which acts on a completely different class of genes transcribed by Pol II. Their findings illustrate that the elongation stage of transcription is a much more specific regulator of gene expression than previously believed.
"About fifteen years ago, transcriptional elongation control was not considered all that important for the regulation of gene expression," says Shilatifard of the standard biology textbook descriptions of RNA transcription, which assume that the molecular machinery that supported transcription elongation was one-size-fits-all. "Once RNA polymerase II departed from the promoter regions, it didn't matter all that much what happened next," he says.
Transcriptional elongation is the step following promoter clearance and the step before termination, and was considered to be largely unregulated. The old metaphor was a train running on tracks. "Polymerase is the train. It sat at the promoter -- which would correspond to the station," Shilatifard explains. "The polymerase train would leave the promoter/station and before long would arrive at the end of the gene. The process of the train traveling between the station and the endpoint of the gene -- is considered elongation."
The latest findings derail the train metaphor. "We have shown that there are specific classes of elongation factors for different classes of genes. Therefore, much more is involved than a train simply following a predestined track," he says. "Years ago, B.F. Goodrich (the tire company) advertised that, 'for every road, there is a tire'. What we are learning is that for every class of genes, there seems to be a specific class of elongation factors. The specificity of the complexes seems to control which classes of genes are transcriptionally regulated," says Shilatifard.
Edwin Smith, Ph.D., a research scientist in Shilatifard's lab, identified LEC in Drosophila cells while biochemically dissecting the proteins associated with theDrosophila homolog of the ELL protein. In human cells, where ELL is found within the SEC, it is required to induce the expression of a class of genes specific for the pathogenesis of a subtype of genes involved in acute leukemia.
This type of leukemia results when, through a process known as translocation, the mixed lineage leukemia (MLL) gene becomes fused to any of a number of seemingly unrelated genes. In earlier studies, Shilatifard's group found that many of MLL's fusion partners, including ELL, belong to the SEC. When MLL fuses with any of these unrelated partners, the whole SEC, much like an entourage, now follows MLL to its normal target genes misregulating their elongation and ultimately causing leukemia.
While humans have three ELL genes, fruit flies have only one ELL, but its structural similarity to the human ELLs suggested an evolutionarily conserved and vital function. To find out more about ELL's function in both creatures, Smith searched forDrosophila interaction partners in collaboration with Michael Washburn, Ph.D., and Laurence Florens, Ph.D., who head proteomics at the Stowers. They used their multi-dimensional protein identification technology, or MudPIT, to identify a set of relatively uncharacterized proteins in Drosophila that associate with the C-terminus of ELL in a complex the Shilatifard lab named the "Little Elongation Complex" or LEC.
When Smith knocked down LEC subunits in fruit flies and analyzed the global expression pattern defect with Alexander Garrett, Ph.D., a bioinformatician in the Shilatifard lab, they found that the expression levels of small nuclear RNA (snRNA) genes plummeted. Unlike other RNAs transcribed by RNA pol II, these snRNA molecules are not translated into proteins, instead they team up with proteins to form small nuclear ribonucleoproteins (snRNPs) known by the cheerful name of "snurps." They form the spliceosome, which edits messenger RNA after it is transcribed from DNA. Smith, Garrett, and Chengqi Lin, a graduate student in Shilatifard's laboratory, also demonstrated that this function of LEC is highly conserved from Drosophila to mammals.
"The specialization of the SEC and LEC complexes for mRNA and snRNA-containing genes, respectively, suggests the presence of specific classes of elongation factors for each class of genes transcribed by RNA polymerase II, which is of fundamental significance," says Smith.
"The next step is to figure out what other classes of genes use other classes of elongation factors. And what are the differential mechanisms of recruitment to RNA Polymerase II on different classes of genes? Once we get a handle on these distinct classes of genes, we hope to be able to modify different classes of genes by modifying these elongation factors." This would be new perspective regarding basic biology and clinical intervention, Shilatifard believes.
Researchers who also contributed to the work include Janet Thornton, Nima Mohaghegh, Deqing Hu, Anita Saraf, Selene K. Swanson, and Christopher Seidel of the Stowers Institute for Medical Research, as well as Jessica Jackson and Joel C. Eissenberg in the Edward A. Doisy Department of Biochemistry and Molecular Biology at the Saint Louis University School of Medicine, Saint Louis, Missouri.
The study was supported in part by the Stowers Institute for Medical Research, and the National Cancer Institute.
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Source: http://www.sciencedaily.com/releases/2011/12/111222133330.htm
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Forget the Pritchetts and the Dunphys. Charlie Sheen has given new meaning to the term "modern family."
The actor posted a photo this week of himself, ex-wife Denise Richards and three children at an undisclosed tropical location. Two of those children, twins Sam and Lola, belong the former couple. The third, six-month old Eloise, was adopted this year by the terrible actress.
"What's better than a modern family vacation!?! love spending winter break w/ @denise_richards & my kids!" Sheen wrote on his WhoSay account, having clearly come a long way from a few months ago.
Has Sheen finally realized the true definition of winning? It's all about family, people.
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