rugger megalithic: April 2013

Tuesday, April 30, 2013

Obama: Cuts means US could lose years of research

WASHINGTON (AP) ? President Barack Obama says the U.S. could lose years of scientific research as a result of automatic spending cuts that have hit federal agencies.

He says instead of racing ahead to the next cutting edge, American scientists are wondering whether they'll be able to develop any new products at all.

He says the U.S. can't afford to stand still for two or three years.

With Obama's blessing, Congress has already acted to fix flight delays that emerged when air traffic controllers were furloughed due to the cuts. But Obama is still pushing a broader plan to replace all the cuts.

Obama spoke at the 150th anniversary of the National Academy of Sciences. He says as long as he's president, the U.S. will continue to invest in science and innovation.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-29-Obama-Science/id-a38d95f5e08c41f08ec3bd3a3d420870

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Monday, April 29, 2013

Comparing proteins at a glance: Technique for easy comparisons of proteins in solution

Apr. 29, 2013 ? A revolutionary X-ray analytical technique that enables researchers at a glance to identify structural similarities and differences between multiple proteins under a variety of conditions has been developed by researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab). As a demonstration, the researchers used this technique to gain valuable new insight into a protein that is a prime target for cancer chemotherapy.

"Proteins and other biological macromolecules are moving machines whose power is often derived from how their structural conformations change in response to their environment," says Greg Hura, a scientist with Berkeley Lab's Physical Biosciences Division. "Knowing what makes a protein change has incredible value, much like knowing that stepping on a gas pedal makes the wheels of a car spin."

Hura led the development of what is being called a structural comparison map for use with small angle X-ray scattering (SAXS), an imaging technique for obtaining structural information about proteins and protein complexes in solution. Cynthia McMurray, a biologist with Berkeley Lab's Life Sciences Division, provided the cancer-relevant protein used to test the new SAXS structural comparison map.

Says McMurray, "In biology, the first step in correcting a problem, such as the formation of a cancerous lesion, is understanding the conditions under which the problem arose. With the SAXS structural comparison map, we can compare multiple protein structures en masse and quickly identify areas of interest."

Greg Hura, Helen Budworth and Cynthia McMurray, shown here at the Advanced Light Source, developed a structural comparison map for SAXS imaging and tested it on a chemotherapeutic target protein. (Photo by Roy Kaltschmidt, Berkeley Lab)

Hura is the lead author and McMurray one of two corresponding authors of a paper in the journal Nature Methods that describes this research. The paper is titled "Comprehensive objective maps of macromolecular conformations by quantitative SAXS analysis." Also a corresponding author is John Tainer, who holds joint appointments with Berkeley Lab's Life Sciences Division and the Scripps Research Institute. The other authors are Helen Budworth, Kevin Dyer, Robert Rambo and Michal Hammel.

In perhaps no other area of science does the maxim "function follows form" hold more true than for proteins and protein complexes. The structural conformations created by the folding, twisting and turning of a protein's amino acid chain can allow or prevent the protein from doing what it's supposed to do and this can mean the difference between a healthy and an unhealthy cell. A protein can assume multiple distinct conformational states as it undergoes various chemical processes such as phosphorylation, nucleotide or ligand binding, ATP hydrolysis or the formation of complexes.

The most widely used technique for determining a protein's structure remains crystallography, but many proteins and protein complexes can't be crystalized. Furthermore, though precise, crystallography is a low-throughput process that can only capture one conformational state at a time. Enter SAXS, a high-throughput technique that can image any protein or protein complex in solution under any condition, and provide nanoscale resolution for distinguishing and characterizing the different conformational states that flexible biological macromolecules such as proteins can assume.

"With SAXS, there are relatively few restraints on conditions, construction, concentration or solution chemistry," Hura says. "However, analytical methods have not kept pace with the hardware. While there are many factors that may induce a protein to undergo structural changes, these factors are difficult to predict. Our structural comparison map technique gives us a high-throughput screening capability. The combination of SAXS and our maps allows us to highlight those factors that make the biggest difference in structural conformations. We're also able to track trends and identify intermediate states and other factors that shift equilibrium from one structure to another."

The data in a structural comparison map is presented in the form of a color-coded checkerboard with similarity scores displayed as gradients moving from red, indicating high, to white, indicating low, and various shades of orange and yellow in between.

"With structural comparison maps, I can immediately see which structures under which conditions are the same and which are not," says McMurray. "The maps provide both structural and chemical information and enable us to identify those conformations we should be looking at."

To test the structural conformation map technique, co-author Budworth, a member of McMurray's research group, prepared samples of a protein known as MutS?, an inviting chemotherapeutic target because of its ability to remove problematic DNA that can lead to cancer and other genetic mutations.

"MutS? is a heterodimer whose two macromolecules undergo an ordered series of nucleotide-dependent steps to initiate DNA repair," Budworth says. "Each discrete nucleotide-bound state is a conformational state decision point that primes the next pathway step. A mechanistic understanding of these steps is crucial to learning how cells avoid mutation."

Says McMurray, "Initially this was a very big puzzle because MutS? had no crystal structure, nor could we take a look at any one conformational state and say this is good or this is bad. The structural conformation maps allowed us to characterize the different conformational states individually and then compare them to one another. We discovered that DNA has surprisingly little impact on MutS? conformational structures, a fact that was not evident from biochemical measurements, but obvious when examining the maps."

From the SAXS imaging and structural conformation map analysis, McMurray and her group believe that DNA is sculpted to the protein conformation and that nucleotide-binding drives MutS? conformational changes. This, they say, holds implications for future cancer therapies.

The MutS? samples were subjected to SAXS at the SIBYLS beamline of Berkeley Lab's Advanced Light Source, a synchrotron that generates premier beams of X-ray and ultraviolet light for scientific research. The acronym SIBYLS stands for Structurally Integrated Biology for Life Sciences. The beamline is maintained by Berkeley Lab's Life Sciences Division under the direction of corresponding author Tainer.

Says Tainer, "The structural comparison map technique is a big step forward in the development of tools that will help biologists use the full potential of the awesome throughput we expect to achieve with the next generation of light sources."

This research was supported by funds from the DOE Office of Science and from the National Institutes of Health.

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The above story is reprinted from materials provided by DOE/Lawrence Berkeley National Laboratory.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Greg L Hura, Helen Budworth, Kevin N Dyer, Robert P Rambo, Michal Hammel, Cynthia T McMurray, John A Tainer. Comprehensive macromolecular conformations mapped by quantitative SAXS analyses. Nature Methods, 2013; DOI: 10.1038/nmeth.2453

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_environment/~3/_XQpz2Ub8Bw/130429130545.htm

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The integrated prom was a whopping success (Americablog)

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Weather postpones trade center's ascent to tallest

NEW YORK (AP) ? One World Trade Center already is New York's tallest building.

And when the last pieces of its spire eventually rise to the roof, the 104-floor skyscraper that replaces the fallen twin towers will be just feet from becoming the highest in the Western Hemisphere.

Officials had hoped that would happen Monday, but the weather did not cooperate and it was postponed due to high winds. The event will be rescheduled when conditions permit.

The Port Authority of New York and New Jersey says the spire pieces and a steel beacon will be lifted at a later date from the rooftop to cap the building at 1,776 feet.

Installation of the 800-ton, 408-foot spire began in December, after 18 pieces were shipped from Canada and New Jersey.

The spire will serve as a world-class broadcast antenna.

With the beacon at its peak to ward off aircraft, the spire will provide public transmission services for television and radio broadcast channels that were destroyed on Sept. 11, 2001, along with the trade center towers.

Overlooking the Statue of Liberty and Ellis Island, the high-rise is scheduled to open for business in 2014.

The tower is at the northwest corner of the site, which is well on its way to reconstruction with the 72-story 4 World Trade Center and other buildings.

Monday's postponed celebration of the reconstructed trade center was to come days after a grisly reminder of the terror attack that took nearly 3,000 lives: the discovery of a rusted airplane part wedged between a nearby mosque and an apartment building ? believed to be from one of the hijacked planes that ravaged lower Manhattan.

As officials prepared to erect the spire, the office of the city's chief medical examiner was working in the hidden alley where debris may still contain human remains.

The new tower's crowning spire is a joint venture between the ADF Group Inc. engineering firm in Terrebonne, Quebec, and New York-based DCM Erectors Inc., a steel contractor.

The tallest building in the Western Hemisphere is the Willis Tower in Chicago. The world's tallest building, topping 2,700 feet, is in Dubai.

Source: http://news.yahoo.com/weather-postpones-trade-centers-ascent-tallest-153256811.html

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Obama Cracks Birther Joke: 'I'd Rather Keep' My Presidential Library 'In The United States' (VIDEO)

Chief of Staff Gen. Raymond T. Odierno, from left, Michael Scherer, White House correspondent for TIME, late-night television host Conan O'Brien and first lady Michelle Obama attend the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

US-POLITICS-ENTERTAINMENT-WHCA-DINNER

Comedian Conan O'Brien (L) smiles as US President Barack Obama (C) and US first lady Michelle Obama arrive for the White House Correspondents? Association Dinner April 27, 2013 in Washington, DC. Obama attended the yearly dinner which is attended by journalists, celebrities and politicians. AFP PHOTO/Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

Barack Obama

President Barack Obama looks to the podium during the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

US-POLITICS-ENTERTAINMENT-WHCA-DINNER

Comedian Conan O'Brien (L) and US first lady Michelle Obama joke during the White House Correspondents? Association Dinner April 27, 2013 in Washington, DC. Obama attended the yearly dinner which is attended by journalists, celebrities and politicians. AFP PHOTO/Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

Barack Obama, Conan O'Brien, Michelle Obama, Michael Clemente

Late-night television host Conan O'Brien, from left, first lady Michelle Obama, Michael Clemente, Executive Vice President of Fox News, and President Barack Obama attend the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

US-POLITICS-ENTERTAINMENT-WHCA-DINNER

Comedian Conan O'Brien listens during the White House Correspondents? Association Dinner April 27, 2013 in Washington, DC. Obama attended the yearly dinner which is attended by journalists, celebrities and politicians. AFP PHOTO/Brendan SMIALOWSKI (Photo credit should read BRENDAN SMIALOWSKI/AFP/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Alicia Quarles attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Megan Hilt attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Morena Baccarin attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Musician John Legend attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Model Chrissy Teigen attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

US-POLITICS-ENTERTAINMENT-WHCA-DINNER

Entertainer John Legend arrives at the annual White House Correspondents' Association dinner in Washington DC, April 27, 2013. AFP Photo/ Chris KLEPONIS (Photo credit should read CHRIS KLEPONIS/AFP/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Musician Psy attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

Steven Spielberg

Director Steven Spielberg uses his smart phone during the White House Correspondents' Association Dinner at the Washington Hilton Hotel, Saturday, April 27, 2013, in Washington. (AP Photo/Carolyn Kaster)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Amy Poehler attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Claire Danes attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Julia Louis-Dreyfus attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Kerry Washington attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Rebel Wilson and Olympic Gymnist Gabby Douglas attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Kate Mara attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Aasif Mandvi and Ty Burrel attend the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Al Sharpton and Chris Matthews attend the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Emily Mortimer attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Connie Britton attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Patricia Arquette attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: John Oliver and Kate Oliver attend the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actor Ryan Kwanten attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Jessica Pare attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actor Justin Bartha attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Julie Bowen attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: NFL player Victor Cruz (L) and Elaina Watley attend the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Ty Burrell attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Olivia Munn attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

TIME/CNN/PEOPLE/FORTUNE Pre-Dinner Cocktail Reception

WASHINGTON, DC - APRIL 27: Jeffrey Katzenberg, Time Magazine Managing Editor Rick Stengel and Steven Spielberg attend the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Larry Busacca/Getty Images for Time, Inc)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Elizabeth Banks attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Aasif Mandvi attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Sofia Vergara attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Michelle Dockery attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actress Constance Zimmer attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actor Tony Goldwyn attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Thomas Roberts attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Actor Ed Helms attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Korie Robertson and Willie Robertson attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

TIME/CNN/PEOPLE/FORTUNE Pre-Dinner Cocktail Reception

WASHINGTON, DC - APRIL 27: Gerard Butler and Piers Morgan attend the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Larry Busacca/Getty Images for Time, Inc)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Matthew Perry attends the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

2013 White House Correspondents' Association Dinner

WASHINGTON, DC - APRIL 27: Piers Morgan and Gerard Butler attend the White House Correspondents' Association Dinner at the Washington Hilton on April 27, 2013 in Washington, DC. (Photo by Dimitrios Kambouris/Getty Images)

Source: http://www.huffingtonpost.com/2013/04/28/obama-birther-joke_n_3172076.html

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These Japanese Wooden Pens Are Perfectly Elegant

You know, there's nothing quite like finding the perfect writing instrument. It's a wordsmith's holy grail of sorts. And we love these elegant new pens from Japanese brand Miidori.

The smooth ebony and tulipwood pens come in two colors options, and they'll arrive on your doorstep in a nice little box. Sure, they'll run you $65, but a quality pen makes a statement, and you probably won't want to write with anything else. [Monocole via Acquire]

Source: http://gizmodo.com/these-japanese-wooden-pens-are-perfectly-elegant-484695075

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Zach Braff raises $2M on Kickstarter in 3 days

NEW YORK (AP) ? Zach Braff has met his goal on Kickstarter, raising $2 million in three days to fund his follow-up to "Garden State."

The actor-director's crowd-funding campaign follows Rob Thomas' wildly successful use of Kickstarter to finance a movie of the defunct TV series "Veronica Mars." Thomas pulled in $2 million in less than a day, eventually gathering more than $5.7 million in 30 days.

But some observers have criticized Hollywood stars for using the Kickstarter website to dip into the pockets of their loyal fans. Braff has said this is the only way for him to direct his first film since "Garden State" with final cut and his desired casting.

After passing his goal Saturday, the "Scrubs" star said on Twitter: "I will not let you down. Let's go make a killer movie."

Source: http://news.yahoo.com/zach-braff-raises-2m-kickstarter-3-days-205951957.html

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Car bomb blasts kill 18 in Iraqi Shi'ite provinces

BAGHDAD (Reuters) - Car bombs in busy Shi'ite Muslim areas of southern Iraq killed at least 18 people on Monday, medics and police sources said, taking the week's death toll to nearly 200 as sectarian violence intensifies.

Militant attacks have increased as the civil war in neighboring Syria puts further strains on fragile Sunni-Shi'ite relations, and tensions are at their highest since U.S. troops left Iraq more than a year ago.

Security forces' raid on a Sunni protest camp near Kirkuk last Tuesday triggered clashes that quickly spread to other Sunni areas in western and northern provinces.

The first of two blasts in Amara, 300 km (185 miles) southeast of Baghdad, ripped through a market where people were meeting to eat breakfast, and the second hit an area where laborers were gathering to look for daily work.

At least nine people were killed and 40 wounded in the Amara explosions, the sources said.

Another car bomb exploded in a market in Diywaniya, 150 km south of Baghdad, killing two people, police said.

"I was preparing to go to work when a big explosion shook my house and broke the glass in all the windows," said Woody Jasim. "I ran outside, the explosion was near my house and bodies were everywhere," he said.

A bomb in a parked car went off near a busy market in Kerbala, killing at least three people and a further four people were killed in an explosion near a Shi'ite worship site in Mahmudiya, about 30 km south of Baghdad.

No group immediately claimed responsibility for the attacks, but car and suicide bombings are trademarks of Sunni Islamist al Qaeda's Iraq wing, the Islamic State of Iraq.

Sunnis have been protesting since December against what they see as marginalization since the U.S.-led invasion overthrew dictator Saddam Hussein in 2003 and empowered majority Shi'ites.

The demonstrations had eased in the past month, but this week's army raid on a protest camp in Hawija, near Kirkuk, 170 km north of Baghdad, stoked Sunni anger and appears to have given insurgents more momentum.

(Reporting by Aref Mohammed in Basra, Kareem Raheem in Baghdad and Emad al-Khuzaie in Diywaniya; Writing by Suadad al-Salhy; Editing by Louise Ireland and Isabel Coles)

Source: http://news.yahoo.com/three-car-bomb-blasts-kill-11-iraq-shiite-060813023.html

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Conversion from 'bad' fat to good fat

Apr. 28, 2013 ? Scientists from ETH Zurich have shown for the first time that brown and white fat cells in a living organism can be converted from one cell type to the other. Their work, using mice as a model organism, provides important new insights into the origin of brown fat cells, which is a prerequisite for the development of successful anti-obesity therapies.

Two types of fat cells can be found in mammals and hence in humans: White fat cells function mainly as highly flexible energy stores which are filled in times of calorie abundance. The fat is stored in the form of lipid droplets, which are mobilized when energy is needed. Diametrically opposed in function are the so-called brown adipocytes: These cells specialize in burning energy in the form of fat and sugar to produce heat. New-born babies possess substantial amounts of brown fat and utilize it to maintain body temperature. Since it was recently shown that brown adipocytes also exist in adult humans, research has focused on understanding how brown adipocytes are formed. The ultimate goal of these efforts is to increase brown adipocyte number and activity in obese humans, allowing them to burn excess calories and thus reduce weight.

Against the current belief

It is known that both humans and mice can adapt to cold temperatures by forming brown fat cells within their white fat depots. These cells are called "brite" fat cells (brown-in-white) and are less common at warmer versus colder temperatures. However, the origin of these special brown adipocytes has remained a matter of debate. The prevalent hypothesis was that brite cells are formed from special precursor cells and are removed when no longer needed. The alternate idea of a direct interconversion between white and brown fat cells gained less attention. By demonstrating that this interconversion does occur and is one of the main contributors to brite fat cell formation, the current belief has been challenged.

Genetically labelled fat cells

To demonstrate how brite fat cells are formed the researchers in the laboratory of Christian Wolfrum, a professor at the Institute of Food, Nutrition and Health, generated mice that allowed them to genetically label specific fat cells. These animals were kept in a changing environment: starting at 8?C for a week and for several weeks afterwards at normal room temperature. During the cold exposure, the mice formed brown adipocytes in their white fat depots -- a process called "britening." After warm adaptation the fat tissue turned white again. Using the genetic markers the scientists concluded from these experiments that white fat cells can convert into brown fat cells and vice versa. As humans have the same type of cells as mice it is likely that the same process occurs in humans upon cold stimulation.

Treatments against obesity

"To develop new treatment strategies we need to find ways to convert white into brown adipocytes," says Wolfrum. Most of the research has focused on identifying the precursor cells for brown fat cells, an approach that may be insufficient. Future work will address the question of how to manipulate this interconversion process either by pharmacological or by nutritional means.

This approach would represent a novel strategy. "Current anti-obesity therapies target the energy intake side of the equation by controlling appetite and the uptake of nutrients," says Wolfrum. The pharmacological treatments that are available are not very efficient and usually are associated with side effects. In contrast, this novel approach to treat obesity would target the energy expenditure side of the equation by promoting brown fat formation.

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Story Source:

The above story is reprinted from materials provided by ETH Zurich, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Matthias Rosenwald, Aliki Perdikari, Thomas R?licke, Christian Wolfrum. Bi-directional interconversion of brite and white?adipocytes. Nature Cell Biology, 2013; DOI: 10.1038/ncb2740

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/3LfJOKXIqoE/130428144925.htm

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Thirteen dead, dozens hurt during Mexican prison riot

MEXICO CITY (Reuters) - Thirteen people were killed and some 65 injured in a prison riot on Saturday in the central Mexican state of San Luis Potosi, local officials said.

A fight broke out before daybreak among prisoners in a cell block in the La Pila prison in the state capital of San Luis Potosi, and state police re-established control by the morning, officials said.

Concepcion Tovar, head of the state's prison system, told reporters that at least 100 inmates participated in the riot, which she blamed on a gang that had been harassing and robbing other inmates.

State officials said via social media that 13 people were killed and about 65 were injured in the riot. They did not make clear whether all those killed or injured were inmates.

The deaths were caused by sharp objects and other improvised weapons, Tovar said. It was unclear if the violence was linked to drug gangs, whose turf wars and battles over trafficking routes to the United States have spread across Mexico.

Deadly riots have repeatedly rocked the country's overcrowded prisons, which house inmates from different gangs.

Killings linked to organized crime fell 14 percent to 4,249 in the first four months of the presidency of Enrique Pena Nieto, who took over in December and vowed to reduce the violence that has marred Latin America's second biggest economy.

Nearly 70,000 people were killed during the 2006-2012 term of former President Felipe Calderon, who sent the military to fight drug cartels. An additional 27,000 are missing, according to official data.

(Reporting by Anahi Rama; Editing by Bill Trott and Mohammad Zargham)

Source: http://news.yahoo.com/thirteen-dead-dozens-hurt-during-mexican-prison-riot-214613768.html

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Saturday, April 27, 2013

CA-NEWS Summary

Anger on streets as Bangladesh building toll passes 300

DHAKA (Reuters) - Bangladesh textile workers vented their anger on Friday, burning cars and clashing with police, as the death toll passed 300 following the collapse of a building housing factories that made low-cost garments for Western brands. Miraculously rescuers were still pulling people alive from the rubble - 72 since daybreak following 41 found in the same room overnight - two days after the eight-storey building collapsed on the outskirts of the capital, Dhaka.

Obama: Chemical weapons use in Syria would be "game changer"

WASHINGTON (Reuters) - U.S. President Barack Obama warned President Bashar al-Assad on Friday that any use of chemical weapons in Syria's civil war would be a "game changer" but cautioned that intelligence assessments that such weapons had been deployed were still preliminary. Speaking a day after the White House said for the first time that Assad's government had likely used chemical weapons on a small scale, Obama talked tough while appealing for patience as he sought to fend off pressure at home and abroad for a swift U.S. response.

Fire kills dozens in Russian psychiatric hospital

RAMENSKY, Russia (Reuters) - Thirty-eight people were killed, most of them in their beds, in a fire that raged through a psychiatric hospital near Moscow on Friday, raising questions about the care of mentally ill patients in Russia. The fire, which broke out at around 2 a.m. (6 p.m. ET on Thursday), swept through a single-storey building at the hospital, a collection of wood and brick huts with bars on some windows that was home to people sent there on grounds of mental illness by Russian courts.

Boston bomb suspect moved to prison from hospital

BOSTON (Reuters) - Boston Marathon bombing suspect Dzhokhar Tsarnaev has been moved to a prison medical center from the hospital where he had been held since his arrest a week ago while recovering from gunshot wounds, U.S. officials said on Friday. The 19-year-old ethnic Chechen, wounded in a late-night shootout with police on April 18 hours after authorities released pictures of him and his older brother as suspects, was charged on Monday and could face the death penalty if convicted. His brother, Tamerlan Tsarnaev, 26, died in the shootout.

"Evidence" of Syria chemical weapons use not up to U.N. standard

AMSTERDAM (Reuters) - Assertions of chemical weapon use in Syria by Western and Israeli officials citing photos, sporadic shelling and traces of toxins do not meet the standard of proof needed for a U.N. team of experts waiting to gather their own field evidence. Weapons inspectors will only determine whether banned chemical agents were used in the two-year-old conflict if they are able to access sites and take soil, blood, urine or tissue samples and examine them in certified laboratories, according to the Organisation for the Prohibition of Chemical Weapons (OPCW), which works with the United Nations on inspections.

Islamist says Egypt should press on with judge reforms

CAIRO (Reuters) - Egypt's Islamist-dominated parliament must move quickly to adopt judicial reforms that have sparked a revolt by judges, the deputy leader of the Muslim Brotherhood's political arm argued on Friday. The proposed reforms, which would get rid of more than 3,000 judges by lowering the retirement age, have widened the rift between President Mohamed Mursi's government and a judiciary seen by its critics as a last bastion of the old regime that was toppled in the 2011 revolution.

Top British publicist charged with 11 sex assaults

LONDON (Reuters) - Celebrity publicist Max Clifford on Friday became the first high profile figure to be charged in a wide-ranging investigation into a sex scandal that has grabbed front page headlines in Britain in recent months. Clifford, 70, was charged with 11 counts of indecent assault, prosecutors said, including on two underage girls, after being arrested in December as part of an investigation into sex crime allegations against the late Jimmy Savile.

Bombs kill at least 20 across Iraqi capital

BAGHDAD (Reuters) - Bomb blasts in Baghdad killed at least 20 more people on Friday at the end of a week of bloodshed that prompted a United Nations envoy to warn Iraq was "at a crossroads". More than 160 people have been killed since Tuesday, when troops stormed a Sunni protest camp near Kirkuk, triggering clashes that quickly spread to other Sunni areas in western and northern provinces.

Russian court denies punk band convict Tolokonnikova parole

MOSCOW (Reuters) - A Russian court refused to release from prison one of two jailed members of the Pussy Riot punk band so that she can look after her young daughter. The court on Friday rejected Nadezhda Tolokonnikova's appeal for parole eight months after she was handed a two-year prison sentence for the band's performance of a "punk prayer" in Moscow's main Russian Orthodox cathedral.

Bosnian regional president arrested in graft probe

SARAJEVO (Reuters) - The president of Bosnia's autonomous Muslim-Croat federation and 19 others were arrested on Friday in an anti-corruption probe that also targeted the offices of the regional government, a spokesman for the state prosecutor said. The raid on Zivko Budimir's Sarajevo office and the regional government in the southern town of Mostar is the most high-profile anti-graft operation in Bosnia since independence more than two decades ago.

Source: http://news.yahoo.com/ca-news-summary-023356509.html

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Growth falls short of forecasts, weakness ahead

By Lucia Mutikani

WASHINGTON (Reuters) - The economy regained speed in the first quarter, but not as much as expected, heightening fears it could struggle to cope with deep government spending cuts and higher taxes.

Gross domestic product expanded at a 2.5 percent annual rate, the Commerce Department said on Friday, after growth nearly stalled in the fourth quarter. Economists had expected a 3.0 percent growth pace.

"It wasn't the bang-up start to the year we had hoped for, and the signals from March suggested that we will only decelerate from here," said Avery Shenfeld, chief economist at CIBC World Markets in Toronto.

Growth rebounded in the early part of 2013 but data ranging from employment to retail sales and manufacturing weakened substantially in March. It appears the factory sector slowed further in April and many forecasters expect the economy's softness to persist into the third quarter before a convincing revival emerges, given belt-tightening in Washington.

A 2 percent payroll tax cut expired at the start of the year and $85 billion in mandatory spending cuts, known as the sequester, started to take hold at the beginning of March.

Second-quarter growth is expected to come in around a 1 percent pace, with growth for the full year seen around a sluggish 2 percent, about the same as in the prior three years.

"It certainly seems like we are in store for a significantly lower rate of growth than we saw here in the first quarter," said Sam Bullard, a senior economist at Wells Fargo Securities in Charlotte, North Carolina.

Government spending has already been on a downward path.

In the first three months of the year, it fell at a 4.1 percent pace as defense outlays dropped sharply for a second straight quarter. It has now moved lower in 10 of the last 11 quarters.

"The decline in government spending over the past two quarters is the biggest six-month contraction since the Korean war ended," Paul Ashworth, chief U.S. economist at Capital Economics in Toronto said in a research note.

SUPPORT FOR FED STIMULUS

In the fourth quarter of last year, the economy had expanded at only a 0.4 percent pace.

A big part of the pick-up in activity in the first quarter was due to the filling up of silos by farmers after a drought last summer decimated crop output. Removing inventories, the growth rate was a tepid 1.5 percent, a slowdown from a comparable 1.9 percent in the fourth quarter.

Still, most areas of the economy contributed to growth, with the exception of government, the trade sector and investment by businesses in offices and other commercial buildings.

While consumer spending increased solidly, it came at the expense of saving, which does not bode well for the future.

A separate report showed worries about finances sapped consumer morale in April, offering another potentially troubling harbinger. The Thomson Reuters/University of Michigan's final reading on the overall index on consumer sentiment fell to 76.4 last month from 78.6 in March.

Stocks on Wall Street fell on the data, while prices for Treasury debt rose and the dollar weakened against the yen.

The GDP report, which also showed a deceleration in inflation, provided ammunition for the Federal Reserve to maintain its monetary stimulus. The U.S. central bank, which meets next week, is widely expected to keep purchasing bonds at a pace of $85 billion a month.

"It will give doves the upper hand at next week's Federal Reserve meeting," said Diane Swonk, chief economist at Mesirow Financial in Chicago. "Don't expect to see any tapering of asset purchases or a slowdown in the growth of the Fed's balance sheet anytime soon."

Consumer spending, which accounts for more than two-thirds of U.S. economic activity, rose at a 3.2 percent pace - the fastest since the fourth quarter of 2010.

The increase came despite the higher taxes and steeper gasoline prices. Households, however, had to cut back on saving as incomes dropped at a 5.3 percent rate, the steepest descent since late 2009.

The saving rate - the percentage of disposable income households are socking away - fell to 2.6 percent, the lowest since the fourth quarter of 2007, from 4.7 percent in the final three months of last year.

INFLATION SLOWDOWN

Despite the spike in gasoline prices, inflation pressures were benign. Inflation rose at a 0.9 percent rate, the smallest gain since the second quarter of 2012 and a sharp slowdown from the 1.6 percent pace logged in the fourth quarter.

A core measure that strips out food and energy costs rose at a 1.2 percent rate.

The lack of inflation should come as welcome relief for American households, but it could cause some nervousness at the U.S. central bank, which aims to keep inflation close to 2 percent.

Business spending on equipment and software slowed sharply, and homebuilding also moderated, although it marked an eighth straight quarter of growth. Housing added to GDP last year for the first time since 2005.

While exports rebounded, they were outpaced by a surge in imports, resulting in a trade deficit that cut off half a percentage point from output.

(Editing by Andrea Ricci and Tim Ahmann)

Source: http://news.yahoo.com/growth-falls-short-forecasts-weakness-ahead-045320313.html

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Samsung's official Q1 earnings show $6.4 billion in net profit

Samsung Electronics has released its Q1 2013 numbers and as it predicted a few weeks ago, business continues to boom. Operating profits are 8.78 trillion won as predicted, while net profit is up to 7.15 trillion won ($6.4 billion), up sharply from the same quarter last year when its net profit was 5.50 trillion won. Last year at this time we were still anticipating details on the Galaxy S III, but this time around Samsung is on the eve of its worldwide launch for the Galaxy S 4, which should push sales even higher. According to the documents, it's maintained a "steady pace" for Galaxy S III sales, while Note II sales increased and the Tab2 series increased momentum. The news isn't as good for PCs, shipments decreased due to weak demand. earnings in its TV business were also down from last quarter, blamed on the same lower overall market demand noted by LG in its earnings. We're listening in on the earnings call now, we'll have more information on just how it made all that cash (hint: lots of Galaxy phones) in a moment.

Developing...

Filed under: Cellphones, Home Entertainment, HD, Mobile, Samsung

Comments

Source: Yonhap, Bloomberg, Reuters, Samsung (PDF)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/pkQygMFhJoo/

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Documentary about Amy Winehouse planned

Toby Melville / Reuters

By Pamela McClintock, The Hollywood Reporter

Universal Music and acclaimed documentary filmmaker Asif Kapadia are teaming to bring the story of Amy Winehouse's life and career to the big screen.

Focus Features International, a division within the Universal empire, will shop the high-profile project to foreign buyers at next month's Cannes Film Market.

?This is an incredibly modern, emotional and relevant film that has the power to capture the zeitgeist and shine a light on the world we live in in a way that very few films can,? said Kapadia and producer James Gay-Rees.

PHOTOS: Posthumous roles: 15 stars who appeared on the big screen after their death

?Amy was a once-in-a-generation talent who captured everyone's attention; she wrote and sung from the heart, and everyone fell under her spell. But tragically, Amy seemed to fall apart under the relentless media attention, her troubled relationships, her global success and precarious lifestyle. As a society we celebrated her huge success, but then we were quick to judge her failings when it suited us," they added.

Winehouse rose to international fame with her second album, "Back to Black," ?which has sold more than 12 million copies worldwide since its release in 2006. The English artist died in 2011 of alcohol poisoning.

Report: Beyonce to cover Amy Winehouse's "Back to Black" for "Gatsby" soundtrack

?Asif and James have the remarkable ability to bring a moving and thought-provoking story to life, as evidenced by Senna. We look forward to seeing their vision of Amy Winehouse," Focus International co-president Alison Thompson said.

The untitled Winehouse doc reunites Kapadia with producer Gay-Rees; they worked together on the 2010 award-winning doc "Senna," which recounts the life and death of Brazilian car-racing champion Ayrton Senna.

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Gwyneth Paltrow?s Hairy Situation In Revealing Dress (VIDEO)

Gwyneth Paltrow’s Hairy Situation In Revealing Dress (VIDEO)

Gwyneth Paltrow on Ellen show Gwyneth Paltrow revealed that her showstopping dress at this week’s “Iron Man 3″ was almost a disaster, when she found out her butt was showing and that she needed to groom herself properly before hitting the red carpet. The 40-year-old actress, who had just been named the World’s Most Beautiful Woman by People magazine, laughed ...

Gwyneth Paltrow’s Hairy Situation In Revealing Dress (VIDEO) Stupid Celebrities Gossip Stupid Celebrities Gossip News

Source: http://stupidcelebrities.net/2013/04/gwyneth-paltrows-hairy-situation-in-revealing-dress-video/

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Friday, April 26, 2013

Hot ice-cream shop hikes prices to deter custom - The Local

For Berlin ice-cream magnate Niko Robert, business is going a little too well. An unending queue outside his shop is cause for complaint from neighbours and driven him to raise his prices to deter customers.

As warm weather arrived in the capital, so did hordes of hungry ice-cream fans outside one popular vendor in the gentrified Prenzlauer Berg district, wrote Frankfurter Allgemeine Zeitung on Tuesday.

Since opening two years ago, the tiny "Hokey Pokey" shop on Stargarder Strasse has rocketed from insider tip to full-blown hipster hangout. So when 32-year-old Niko Robert reopened his doors in March after the winter break, excitement ensued.

Hankering after scoops of Indian Mango, Rocky Road and Pistachio, customers line the pavement; bikes, pushchairs and scooters in tow, blocking pedestrians and traffic, and stifling custom to neighbouring businesses, said the paper.

At peak times, the line has been known to snake 50 metres down the road. And once armed with a cone, customers tend to plop down next to the shop to eat, crowding nearby benches and tables.

Now, in the latest gentrification debate to hit the area, the proprietor of an Italian caf? a few doors down has had enough. Robert said she has entered into several arguments with his customers, has been known to swear at him in the street threatened to report him to the police.

The caf? owner, who has not spoken to press, presumably feels the crowds of ice-cream customers drive away her custom, block access and ruin the view from the tables she has set out on the street.

"He's a nice guy, I love his ice-cream," Abdel Muhdi, owner of falafel takeout restaurant "1001 Falafel" over the road told the paper. "The ice-cream shop is doing great business, but right and left of it you can't work anymore."

Now Robert, scared of being shut down by the local Ordnungsamt, has resorted to trying to drive away his customers. First, he shut up shop for three days over last weekend. Then big signs appeared announcing price rises - up from ?1.20 to ?1.60 a scoop, wrote the paper.

Robert says he really just wants to keep his shop open and bring custom down to acceptable levels. "The aim is not to make as much money as possible here," said Robert, pointing out that his expensive ingredients mean high overheads.

The Local/jlb

Source: http://www.thelocal.de/society/20130425-49361.html

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Prototype Siemens connected lifestyle application shows off their vision of the connected kitchen

One thing that stood out at the recent IFA Global Press Conference in Sardinia, was that connected home appliances are definitely headed our way. We've seen such things as an Android powered oven, but Siemens looks set to connect the whole kitchen in the next couple of years.

What they had to show was a prototype of a future connected lifestyle app, which will offer the facility to control all of your household appliances from your iOS device. On the face of it, it seems such a simple idea, but it's still pretty interesting to see. Within one app, you'll be able to control your washing machine, dishwasher, coffee machine, oven, pretty much the whole kitchen.

For example, their connected refrigerator will take a photograph of the main shelves and of the door every time the door closes. The contents are then viewable from within the iOS app, and it's even smart enough to help decide upon recipes based on what's in your fridge. If you're short on something for that recipe, it'll tell you what you need to pick up from the store. When you're ready to cook, it'll help you set the oven to cook for the right amount of time at the right temperature.

It also works for diagnostics and customer care too. Video calling is built in, so should one of your appliances develop a fault, you can call through to customer care from within the app. They then access your appliance remotely, determine the fault, and if possible action it from their end.

The video above gives a quick rundown, although as this is a prototype we're not looking at seeing this come to life any time soon. Siemens told us that they expect to be shipping the connected appliances within 2 years, by which time things may get yet more advanced. The kitchen may not be the most glamorous application for mobile tech, but it's a room we all use daily. It makes perfect sense that it, too, should become part of our mobile connected lifestyles.

Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/Jpjj3Bx7q5Q/story01.htm

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Best Business Blogs | Content for Reprint

Author: Martie McCabe | Total views: 93 Comments: 0
Word Count: 1167 Date: Fri, 26 Apr 2013 4:27 PM

Online marketing is essential for any business owner in this day and age. There are a ton of ways in which you can target new customers and drum up business. You can do a lot of these things without spending any money at all. The information here can introduce you to Website marketing, and help you build up your online business to achieve higher profits than you ever expected.

When making your website, try to make it visibly appealing with as much interesting content as possible. You need to give your customers the information they need so that they can make informed decisions about their purchases. Repeat information, fluff and unreliable information should be avoided.

To increase the quality of your internet promotion, start blogging. A blog gives you another way to communicate with your customer base. As you increase the breadth of your site, you will cause more visitors to show up.

It can be a bit overwhelming when you try and decide exactly what type of business you want to create. To start off, you need to narrow down all of your interests until you find the one you enjoy the most. Pick something that you like and know much about. Creating a tangible goal will make it much easier to market your website.

The internet is an effective free resource to help evaluate your market approach since you may not be able to afford a marketing consultant for best business blogs. Consider joining up with an online forum, groups in your hometown, or borrowing books from your local library.

One fun marketing campaign is to have a contest on your website that offers great prizes. For instance, make your site like a scavenger hunt with hidden words scattered around the page. Ask visitors to find them. Offer prizes and discounts for those that find them. When customers are involved in the site, they are more likely to feel comfortable making a purchase from you.

Don't overlook the little details. Place your site's title in the top corner of each page. Also, place a description of your site here. Visitors may get to different pages, depending on their search. If they do not know exactly what your page has to offer, they may simply leave.

The language you use on your site should be rich, creative and descriptive, especially for a niche marketing blog. People like adjectives so make sure that you use plenty of them in any item descriptions. Come up with creative turns-of-phrase, and find ways to amaze people with your writing. Engender a desire to come back to your website, just to see what you might say next.

If you are good at writing, write an article about your business and submit it to magazines that accept submissions. Make sure these articles are signed with your full name and contain information about your business. If you get published in an online magazine, include a link to your site. Ask the editors if they would accept some free products or commission on affiliate work if they will put your articles on their site.

Create a well-designed and interesting website. What your website looks like, as well as the content it contains, will have a huge bearing on your degree of success. Interesting articles and a user friendly design will go a long way in keeping visitors on your site. The design should be engaging enough to grab your audience's attention, making them want to keep looking around.

If you want your site to be successful, it should contain rich, entertaining text. You want the information on your website to appear at the front of search engines, but you also want it to be original enough that you will bring in visitors.

To get a better idea of what is most effective with your customers, test your emails. A/B testings is a great option. Develop your email campaign, then focus on changing only one thing. Choose something to compare. For example, you may want to test a couple of different subject lines or intro paragraphs in your marketing copy. You would then send both types of emails out to two different equal-sized subsets of customers, measuring the results. Whichever methods test as the most successful can become the singular method or format you keep to finish out the campaign.

Put yourself in your customers' shoes. Is your site easy to navigate through? Does it offer enjoyment to the reader? Can orders be placed on your website quickly and easily? You don't want to bring in business only to lose it because of a poorly designed website.

Your URL should be memorable, so that people come back. You will want to incorporate your brand name or your business's name into your site address, if you can. Use an URL that will be easy to remember for your customers. They will be more likely to visit your website if they can remember it.

Try to get inside the brain of your customers when creating your website. If you can provide them with the information or products they are searching for, then sooner or later your marketing efforts will have paid off and result in many sales. Ask visitors for their direct input and objective analysis of your site. Ask friends or family, or even ask for comments from those in a marketing forum. Research well and develop a site that will give people the help they need.

When advertising a deal or product include words that make them feel like they are getting a deal. People shop online because they are tired of what their local stores have to offer. Online consumers seek unique products different from what they are used to seeing. By offering a product that is limited in quantity, it will cause customers to snap them up quickly, so that they don't lose out on something that is different or unusual.

People often do not believe everything they read in ads. For years, advertising has been misleading. This makes it very important to support every claim you make on your site as fully as possible. You can use reviews, before-and-after pictures, test reports, and testimonials. Don't claim that your product or service does something you're not able to prove. Your customers should be treated like they're smart and are informed. You should not take advantage of any person -- ever. Build a trustworthy reputation, and customers will flock to your business.

As has been revealed earlier, web marketing is an amazing way to reach out to customers and to bring attention to your business and products. The opportunities are endless and the benefits are immense. By utilizing the information in the article, you can build your customer base and bring new recognition to your company.

Martie McCabe is an internet marketer.. My articles focuses on developing strategies and tips on promoting your blog. Learn more about promoting your blog and blog names. For more articles go to my blog at http://www.empowernetwork.com/10k/best-business-blogs/

1: Article Marketing Strategy: Putting Together a "Class Schedule" For Your Article Topics

Businesses go to so much trouble when there is one sure-fire, simple, very inexpensive way to attract new clients to a business: Teach a free class. That is what article marketing is like. Your articles are just like free classes. You teach your target readers something helpful in your article. Your resource box then says, "If you enjoyed this article you can visit my website and apply what you have learned."

2: Why You Need To Build Multiple Streams of Income For Yourself

Being an entrepreneur and earning multiple streams of income is a dream that many have, but in reality it does take some initial hard work to achieve this. Earning multiple streams of income is the wave of the future, and here are some tips and advice for you when you are looking for ways in which to do this for yourself.

3: Understanding Online Business Success

Starting a home based business to earn income online takes a significant amount of time and energy upfront to get things going. Not seeing results immediately can be discouraging and cause people to give up too early. In this article, we look at the process of starting a home based business and working through the frustrations to be there when the sales come flowing in.

4: What is Cyber Marketing And Why It Is So Important For The Success Of Your Website

Cyber marketing has now become an indispensable segment of e-commerce as well as the internet and World Wide Web related topics. Cyber marketing simply refers to a technique of attracting potential customers by advertising your products or services through such means as websites, emails, and banners.

5: The Best Way To Optimise Your Website SEO For Google Panda

If you want your SEO to work you now need to concentrate on appeasing Google Panda, and to do this you need to know what Google Panda's spiders/bots will be looking for. Find out here how to search engine optimise your website for the latest Google Panda algorithm, and achieve the success you deserve.

Source: http://www.content4reprint.com/internet-marketing/best-business-blogs.htm

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'This Is The End' Exclusive Set Visit: Getting Cabin Fever In A Million-Dollar Mansion

Seth Rogen, Jonah Hill and friends were busy braving the apocalypse when MTV News stopped by.
By Kevin P. Sullivan, with reporting by Josh Horowitz

The cast of "This Is The End"
Photo: Sony Pictures

Source: http://www.mtv.com/news/articles/1706352/this-is-the-end-exclusive-set-visit.jhtml

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PFT: Moon still sees bias against black QBs

Getty Images

We had an initial mock draft because everyone does.

We had a second version of the mock draft because everyone does.

And now we have a final version of the mock draft because I?ve got nothing else to do tonight.

We welcome your comments, criticisms, and questions regarding our sanity.

1.? Chiefs:? Eric Fisher, tackle, Central Michigan.

2.? Jaguars:? Luke Joeckel, tackle, Texas A&M.

3.? Raiders:? Sharrif Floyd, defensive tackle, Florida.

4.? Eagles:? Dion Jordan, defensive end, Oregon.

5.? Lions:? Ezekial Ansah, defensive end, BYU.

6.? Browns:? Dee Milliner, cornerback, Alabama.

7.? Cardinals:? Lane Johnson, tackle, Oklahoma.

8.? Bills: Ryan Nassib, quarterback, Syracuse.

9.? Jets:? Barkevious Mingo, defensive end, LSU.

10.? Titans:? Chance Warmack, guard, Alabama.

11.? Chargers:? Johnathan Cooper, guard, North Carolina.

12.? Dolphins:? Desmond Trufant, cornerback, Washington.

13.? Jets:? Tavon Austin, receiver, West Virginia.

14.? Panthers:? Star Lotulelei, defensive tackle, Utah.

15.? Saints:? Xavier Rhodes, cornerback, Florida State.

16.? Rams:? Cordarrelle Patterson, receiver, Tennessee.

17.? Steelers:? Jarvis Jones, linebacker, Georgia.

18.? Cowboys:? ?Sheldon Richardson, defensive tackle, Missouri.

19.? Giants:? Tyler Eifert, tight end, Notre Dame.

20.? Bears:? Sylvester Williams, defensive tackle, North Carolina.

21.? Bengals:? D.J. Fluker, tackle, Alabama.

22. Rams:? Kenny Vaccaro, safety, Texas.

23.? Vikings:? D.J. Hayden, cornerback, Houston.

24.? Colts:? DeAndre Hopkins, receiver, Clemson.

25.? Jaguars (trade with Vikings):? Geno Smith, quarterback, West Virginia.

26. Packers:? John Jenkins, defensive tackle, Georgia.

27.? Texans:? Robert Woods, receiver, USC.

28.? Broncos:? Tank Carradine, defensive end, Florida State.

29.? Patriots:? Justin Hunter, receiver, Tennessee.

30.? Falcons:? Bjeorn Werner, defensive end, Florida State.

31.? 49ers:? Eric Reid, safety, LSU.

32.? Ravens:? Jonathan Cyprien, safety, FIU.

Source: http://profootballtalk.nbcsports.com/2013/04/24/warren-moon-sees-biases-hurting-black-quarterbacks/related/

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